“MUST READ”
tags: weeklylinks
- With this trove of genetic information, the scientists were able to accurately infer the genomes of more than 100,000 other Icelanders, or almost a third of the entire country.
“From the technical point of
view, these papers are a tour-de-force,” said David Reich, a geneticist at
Harvard Medical School who was not involved in the research.
- Discovering these mutations can shed light on these diseases and point to potential treatments. But many of them are rare, making it necessary to search large groups of people to find them.
TOOLS/TECHNIQUES
tags: weeklylinks
- In this article we highlight some of the different NGS technologies and methods available out there.
- The 4 Important Steps for Western Blot Quantification | Bitesize Bio
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- Review these important concepts about how to correctly quantitate your next Western blot.
- Behind the Bench: Go Digital PCR: Pt 2 – ...
tags: weeklylinks
- This is the second in a six part series to introduce you to digital PCR (dPCR). In this edition, we’ll take a look at how QuantStudio® 3D dPCR from Life Technologies offers simplicity, affordability, and most importantly, absolute quantification attainability.
- Keeping On Top of Housekeeping Genes Bitesize Bio
tags: weeklylinks
- Want to measure how much mRNA you have in a particular sample? Easy! Make some cDNA, add some fluorescent DNA-intercalating dye, pop it into a quantitative real-time PCR (qRT-PCR) machine and Bob’s your uncle! You have your result! Easy right…? Not so fast.
As with any scientific assay,
qRT-PCR requires some optimization. First, you need to test your primers for specificity
and efficiency and second, and most commonly
overlooked, you need to optimize and select your housekeeping gene.
tags: weeklylinks
- If you think all cloning techniques require restriction enzymes or ligases, think again. There are lots of ways you can clone without restriction enzymes or ligases for seamless cloning results. Read below to learn about Topoisomerase cloning, SLIC and Gibson.
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- In a letter to colleagues announcing his departure as the director of the National Cancer Institute, Dr. Harold Varmus, 75, quoted Mae West. “I’ve been rich and I’ve been poor,” he wrote, “and rich is better.”
- FDA Proposes New Approach for the Regulation of NGS-Based Genetic Testing
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- In February of 2015, the US Food and Drug Administration (FDA) released a nine-page paper entitled “Optimizing FDA’s Regulatory Oversight of Next Generation Sequencing Diagnostic Tests—Preliminary Discussion Paper” that, among other ideas, proposed allowing the use of curated third-party databases to support submissions for FDA approval, rather than requiring new studies and the support of existing literature.
tags: weeklylinks
- Ginkgo was founded in 2008 by computer scientist Tom Knight and a group of MIT graduates including Kelly, Reshma Shetty, Barry Canton, and Austin Che. It was selected in 2009 as one of two companies to find better ways to assemble synthetic DNA, funded with $4.1 million through a Scottish initiative.
- As Pharma Collaborations Gain Importance, GSK Opens Second Outpost | Xconomy
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- n San Diego, the GSK office is in a prestigious zip code that includes The Scripps Research Institute, Salk Institute, Sanford-Burnham Medical Research Institute, and Sanford Consortium for Regenerative Medicine—with UC San Diego and scores of biotech startups in close proximity.
- Fujifilm Snaps Up Cellular Dynamics To Grow Stem Cell Business | Xconomy
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- Cellular Dynamics International, an up-and-coming player in the stem cell field and one of Wisconsin’s more promising biotech companies, is being acquired by Fujifilm for $307 million in cash.
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