“MUST READ”
TOOLS/TECHNIQUES
HEALTH/MEDECINE
COMPANIES
o
Qu’est-ce que l’épigénétique ? Dans cet
entretien Edith Heard, professeur au Collège de France, explique la
particularité de cette discipline relativement récente qui s’intéresse au
devenir génétique de nos cellules et représente un nouvel espoir dans la
recherche contre le cancer.
o But now, thanks to scientific
advances such as genetic sequencing and new DNA editing technologies, the
industry is in the midst of a dramatic reversal. Last year investors poured
$3.3 billion into firms that are developing drugs for brain-destroying or
psychiatric illnesses, more than in any of the last ten years, says
NeuroPerspective.
DISRUPTION,
REVOLUTIONTOOLS/TECHNIQUES
o If you want to get the maximum yield
and quality from your next-generation sequencing experiment then you are going
to need to make sure each of the libraries you produce is carefully quantified
ready for pooling and/or loading onto a flow cell. If the quantification goes
wrong you’ll get a bad balance of samples within your pool, and if the loading
goes wrong you might get no data at all!
o In this article I’ll explain the
pro’s and con’s of using qPCR and also discuss some of the other methods people
use; these come with an advisory warning to avoid unless you really understand
their limitations!
o In a paper in Lab on a Chip, scientists from Corning, Inc. and Massachusetts General Hospital
demonstrate a new, microengineered approach for treating cultured cells with
drugs. Instead of growing the cells on flat surfaces, cells are grown on
micro-modified wells plates that contain regular patterns of tiny holes.
o Read any flow cytometry protocol and
somewhere near the beginning will state something to the effect of ‘Place 1
million cells into a tube.’ The question is, faced with that special sample for
THE experiment, how do you determine the number of cells in the tube? First
we'll give a bit of information on why it is important to know the number of
cells you have.
o Bacterial cultures may be much
easier to grow than mammalian cells, but if your yields are suboptimal there
are plenty of parameters to play with. Here we list a few of the things you
should consider to maximize your culture growth.
COMPANIES
o
Unchained
Labs is committed to building the next cool life science tools company. One
that matters. One without old school rules. One with products that'll make
a real difference in the research scientists do every day.
The
first Unchained product, Optim, lets scientists unlock optimal biologic
formulations simply and quickly. For the first time, researchers can measure
multiple protein stability parameters - including denaturing temperature and
aggregation onset temperature - on multiple samples simultaneously. Assays are
high throughput, label-free, ultra-low volume and very easy to run.
SOMETHING DIFFERENT
o Employees are vastly more satisfied
and productive, it turns out, when four of their core needs are met: physical,
through opportunities to regularly renew and recharge at work; emotional, by
feeling valued and appreciated for their contributions; mental, when they have
the opportunity to focus in an absorbed way on their most important tasks and
define when and where they get their work done; and spiritual, by doing more of
what they do best and enjoy most, and by feeling connected to a higher purpose
at work.
