“MUST READ”
HEALTH/MEDECINE
o Traditional forensic methods can’t
differentiate between DNA belonging to identical twins
o Using what’s known as ultra-deep,
next-generation sequencing, a team in Germany has developed a test that claims to reliably identify which twin a biological sample
belongs to
DISRUPTION,
REVOLUTION
tags: NIPT
o The first NIPT was released in
October 2011 by Sequenom. Subsequently, six other companies globally have
released their own NIPTs: Verinata Health, Ariosa Diagnostics and Natera in the
United States, Berry Genomics and Beijing Genomics Institute (BGI) in China,
and Premaitha Health in the UK. As an indication of how valuable this space is,
genomics powerhouse Illumina purchased Verinata in January 2013 for USD$450
million and has publicly stated its plans to develop the first diagnostic
version of the NIPT
o In Europe payers have not been as
responsive. Although the test is currently distributed in over 16 countries
throughout Western and Eastern Europe, most patients will need to pay for the
test out of pocket. Few nationalized health systems and private insurers in
these regions currently reimburse for the test. In the UK, the National Health
Service (NHS) is performing a five-year evaluation program, known as the RAPID
project, to generate its own data and make a more informed decision about
future reimbursement policies.
TOOLS/TECHNIQUES
tags: weeklylinks NGS
o Making a Next Generation Sequencing
(NGS) library can seem a bit daunting to the new user, as failures can be
expensive. But don’t be put off, as NGS library preparation is relatively simple
molecular biology, and can be very easy if you choose to use a commercial kit
from one of the many suppliers.
o I’ve included some handy hints in
this article to get you going on your way to preparing an awesome NGS library.
tags: antibiotic
o The discovery of teixobactin, the
antibiotic, was published in the prestigious journal Nature, and at a time when most of the news in this
area relates to scary drug-resistant superbugs, journalists pounced on the
positive finding.
Researchers
who work on the problem of antibiotic resistance, however, were much less
excited. To put it plainly, they think the media over-hyped the new
"miracle drug" and had several important reservations about
teixobactin and whether it would actually be helpful in humans. Here's
what they said.
tags: weeklylinks antibiotic
o A team from Northeastern
University/Bonn/Novobiotic (and Selcia) has
published a very worthwhile paper in Nature on a new antibiotic, with a new mechanism of
action, via a new discovery technology. The compound itself is not the world-changing
new last line of defense that everyone's hoping for, but it's nothing to sneeze
at, either. And the platform used to find it is worth keeping an eye on.
COMPANIES
o In a deal that shakes up the
full-steam-ahead world of cancer diagnostics, the world’s top oncology drug
company, Roche, said today it’s spending more than $1 billion for a majority
stake in Foundation Medicine and creating a powerful drug-diagnostic
collaboration.
It’s
a significant gamble on the as-yet-unrealized potential of tests that aim for
broad genetic profiles of cancer patients’ tumors, one that Roche hopes can not
only accelerate the impact of its broad range of cancer-fighting drug programs,
but also extend the reach of its global diagnostics business.
SAN
DIEGO and SAINT-OUEN-L'AUMONE, France, Dec. 10, 2013 /PRNewswire/
-- Sequenom, Inc. (NASDAQ: SQNM), a life sciences company providing
innovative testing and genetic analysis solutions, announced that Laboratoire
Cerba has launched its validated noninvasive prenatal test (NIPT) to health
care providers and their patients in France, Belgium, Luxembourg and portions
of the Middle East and Africa. Laboratoire Cerba's test utilizes patented
technology licensed from Sequenom to analyze the relative amounts of
chromosomes 21, 18 and 13 in cell-free fetal DNA obtained from a maternal blood
sample.
tags: weeklylinks
o The San Diego-based DNA sequencing
technology company (NASDAQ: ILMN) plans to consolidate most of its Bay Area
operations — now spread between San Francisco's Mission Bay, Redwood City,
Hayward and Santa Clara — at the 19-acre site off Highway 92 near the base of
the San Mateo Bridge.
tags: weeklylinks
o For the highest paid CEO in this
group, John Martin at Gilead Sciences, the biggest portion of pay came from the
$159 million in option profits he made in 2013, the latest year for which
figures are available. While Gilead’s stock is up more than 350% in the last
five years, that level of growth is dwarfed by the share price increase at
Regeneron of more than 2,000% in the same period.
SOMETHING DIFFERENT
The
Atlantic article tackles Hofstadter’s belief that, contrary to the machine
learning approach, developing AI programmes can be a way of testing out ideas
about the components of thought itself. This idea may be now starting to
re-emerge.
o
Douglas
Hofstadter, the Pulitzer Prize–winning author of Gödel, Escher, Bach,
thinks we've lost sight of what artificial intelligence really means. His
stubborn quest to replicate the human mind.
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