Monday, March 21, 2016

Weekly Links March 21 th, 2016



“MUST READ”
Handful of Biologists Went Rogue and Published Directly to Internet While several influential journals, including Science and Nature, have a stated policy of treating preprints on an equal footing with papers that have not been posted elsewhere, few…
    • Unlike physicists, for whom preprints became a default method of communicating discoveries in the 1990s, biomedical researchers typically wait more than six months to disseminate their work while they submit it — on an exclusive basis — to the most prestigious journal they think might accept it for publication. If, as is often the case, it is rejected, they try another journal. As a result, it can sometimes take years to publish a paper
DISRUPTION, REVOLUTION
    • regulators are still working out how to deal with such creatures, particularly those intended for food or for release into the wild. Concerns abound about safety and ecological impacts. Even the US director of national intelligence has weighed in, saying that the easy access, low cost and speedy development of genome editing could increase the risk that someone will engineer harmful biological agents.
  • In the CRISPR patent fight, the Broad Institute scores big
In the CRISPR patent fight, the Broad Institute scores big in early motions The CRISPR patent dispute has two things in common with the 2016 presidential race: it’s going to last until at least November; and following who’s up and who’s down is enou…
    • To recap: The Broad was granted about a dozen CRISPR patents for genome editing. UC claimed it, and not the Broad, was entitled to them
Under the law at the time, patents go to the first to invent something (they now go to the first to file). The Broad paid for an accelerated review of its key patent application, and was awarded its first in April 2014. UC did not pay for such expedition, and so was left in the dust when that decision came out
The “interference proceeding” now underway at UC’s request will resolve which organization is entitled to the key CRISPR patents.
Is do-it-yourself CRISPR as scary as it sounds? Media reports about the gene-editing technique called CRISPR-Cas9 have generated some doomsday scenarios that the technology would be used, as Wired magazine wrote, to create “designer babies, invasive…
    • Indeed, the current culture of responsibility among DIY biologists, their collaborative style of working and the fact that community labs are open spaces in which everyone can see what is going on reduce, if not eliminate, doomsday scenarios of mutant organisms escaping from basements and causing harm
Here’s what several other experts had to say about do-it-yourself CRISPR
TOOLS/TECHNIQUES
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HEALTH/MEDECINE
Screening for Alzheimer’s Gene Tests the Desire to Know Marty and Matt Reiswig, two brothers in Denver, knew that Alzheimer’s disease ran in their family, but neither of them understood why. Then a cousin, Gary Reiswig, whom they barely knew, wrote …
tags: Pocket
COMPANIES
Editas biotech stock drops by 26 percent over CRISPR patent dispute Gene editing outfit Editas has been one of the most successful tech IPOs of 2016 so far, with shares skyrocketing up 130 percent shortly after the company’s public debut.
tags: Pocket
Can Pharnext make a rare disease drug cheaper? An estimated 2.8 million people worldwide have been diagnosed with a disease known as Charcot-Marie-Tooth disorder, an inherited muscular atrophy condition. The disease causes debilitating muscle weakne…
tags: Pocket
SOMETHING DIFFERENT
    • So-called "autonomous vehicles" have for years been a distant dream but technology advances and a push by Google (GOOGL.O), with its huge financial resources, to introduce a prototype have shifted the race to build them up a gear.
Analysts at Exane BNP Paribas have said they see a $25 billion market for automated driving technology by 2020, with vehicle intelligence becoming "the key differentiating factor". But the brokerage does not expect fully automated cars to hit the road until 2025 or 2030, in part due to regulatory hurdles.
Facebook is eating the world Something really dramatic is happening to our media landscape, the public sphere, and our journalism industry, almost without us noticing and certainly without the level of public examination and debate it deserves.
    • Social media hasn’t just swallowed journalism, it has swallowed everything. It has swallowed political campaigns, banking systems, personal histories, the leisure industry, retail, even government and security. The phone in our pocket is our portal to the world. I think in many ways this heralds enormously exciting opportunities for education, information, and connection, but it brings with it a host of contingent existential risks.
  • Inside the Artificial Intelligence Revolution: Pt. 1 | Rolling Stone
Inside the Artificial Intelligence Revolution: A Special Report, Pt. 1 Has the artificial intelligence revolution taken us to the verge of witnessing the birth of a new species? How long until machines become smarter than us?
tags: Pocket
Inside the Artificial Intelligence Revolution: A Special Report, Pt. 2 How much control of our lives do we want to give over to machines – and to the corporations that build and operate them? It's a weird feeling, cruising around Silicon Valley in a…
tags: Pocket

Friday, March 11, 2016

Weekly Links March 11 th, 2016



DISRUPTION, REVOLUTION
Should you edit your children’s genes? Ruthie Weiss’s basketball team seemed to be minutes away from its fourth straight loss. But even as she stood on the sidelines for a brief rest, the nine-year-old had not given up. She convinced the coach to pu…
For less than $1,000 you can now pull up your entire genome on your smartphone Veritas Genetics was one of the first companies to sequence the entire human genome for less than $1,000 in 2015. It’s now taken that technology a step further by deliver…
Big Data Meets Big Science in San Diego on March 31: The Agenda In less than a Diego to talk about the opportunities that are emerging for tech and software innovation …
TOOLS/TECHNIQUES
When restrictions come in the form of paperwork and approvals, we detest them. Whereas, when the restrictions come in the form of enzymes, we love them, don’t we? Restriction enzymes play a key role in biotechnology research. Read ahead…
HEALTH/MEDECINE
o    The federal Medicare program and private health insurers waste nearly $3 billion every year buying cancer medicines that are thrown out because many drug makers distribute the drugs only in vials that hold too much for most patients, a group of cancer researchers has found. 
The expensive drugs are usually injected by nurses working in doctors’ offices and hospitals who carefully measure the amount needed for a particular patient and then, because of safety concerns, discard the rest.
COMPANIES
Illumina CEO Flatley To Step Aside, deSouza To Take Reins in July Illumina helped usher in the genomic age. Now the company has a new leader. Illumina (NASDAQ: ILMN) today said CEO Jay Flatley would step aside in July after 17 years at the helm, but…
Bio-Rad get the go-head to market Droplet Digital PCR in Europe In the race to develop rapid, highly sensitive cancer diagnostics that can detect the disease when it is little more than a suspicion of rogue cells in the blood stream, liquid biopsies…
Illumina CEO Jay Flatley Built The DNA Sequencing Market. Now He's Stepping Down Jay Flatley is stepping down as chief executive of Illumina, the largest maker of the DNA sequencing machines that have transformed the study of biology and the inventi…
SOMETHING DIFFERENT
    • What is most interesting about the Echo is that it came out of nowhere. It isn’t much to look at, and even describing its utility is difficult. Here is a small, stationary machine that you set somewhere in your house, which you address as Alexa, which performs a variety of tasks — playing music, reading the news and weather, keeping a shopping list — that you can already do on your phone.
  • Women (who invest) in tech: a list of some of the most influential European female VCs - Tech.eu
Women (who invest) in tech: a list of some of the most influential European female VCs Last year in March, Ellen Pao’s high-profile gender discrimination trial against her former employer – Kleiner Perkins Caufield & Byers – started a wide conversat…

Friday, March 4, 2016

Weekly Links March 4 th, 2016



“MUST READ”
Illumina, the Google of Genetic Testing, Has Plans for World Domination You could say that Illumina is to DNA sequencing is what Google is to Internet search, but that would be underselling the San Diego-based biotech company. Illumina’s machines, t…
DISRUPTION, REVOLUTION
Some thoughts on the CRISPR story... For the record, I am always nervous when I speak to reporters (sorry guys). One never really knows how these things will turn out. In this case, I think Erika did a phenomenal job capturing the real complexities …
TOOLS/TECHNIQUES
Bitesize Bio In the modern science era, the words polymerase chain reaction (PCR) are synonymous with a disruptive technology that teleported biomedical research into a new frontier.
HEALTH/MEDECINE
COMPANIES
Illumina Sues Oxford Nanopore In case you missed it, Illumina announced that it is Oxford Nanopore Technologies for violating Illumina’s two patents on nanopore sequencing in Oxford Nanopore’s MinION and PromethION devices. The lawsuits are based on…
With Patent Suit, Illumina Looks to Tame Emerging British Rival Oxford Nanopore Gene-sequencing giant Illumina is like the Standard Oil of the genome age. Except instead of oil it pumps DNA. More than 90 percent of all DNA data is generated by machi…